House Ear Institute logo
sitemap
about newsroom research education children services support
departments scientists conferences administration Technology Transfer
...research

Medical Training and Faculty Appointments:

  • M.D.:  Yonsei University College of Medicine, Seoul, Korea, 1960

  • Postdoctoral Fellowship: Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston, MA, 1965 – 1966

  • Research Associate: Department of Otolaryngology, Ohio State University, 1966-1967

  • Assistant Professor, Associate Professor, Professor, Department of Otolaryngology, Ohio State University, 1967 – 1991.

  • Professor-Emeritus, Department of Otolaryngology, Ohio State University, 1992 – present

  • Adjunct Professor: Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California

 Administrative Appointments:

  • Director, Otological Research Laboratories, Department of Otolaryngology, Ohio State University, 1967 – 1991.

  • Director, Division of Intramural Research and Scientific Director: NIDCD, NIH, 1992-1994

  • Chief, Laboratory of Cellular Biology, DIR, National Institute of Deafness and other Communication Disorders, National Institutes of Health, 1992-1995

 Major Awards Received and Professional Accomplishments:

  • Javits Award, The National Institutes of Health, National Institute on Deafness and Other Communication Disorders, 1986

  • Claude Pepper Award, The National Institutes of Health, National Institute on Deafness and Other Communication Disorders, 1989

  • Shambaugh Prize, Collegium Oto-Rhino-Laryngologicum Amicitiae “Sacrum, Cairo, Egypt, 1982

  • Award of Merit, Association for Research in Otolaryngology, 1993

  • Guyot Prize, University of Groningen, The Netherlands, 1994

  • Magarotto Award, The Antonio Magarotto International Foundation, Rome, Italy, 1998

  • Paparella Award, American Academy of Otolaryngology-Head and Neck Surgery, New Orleans, Louisiana, 1999

  • William Saunders Lectureship Award, 9th Annual Otolaryngology Alumni Symposium, Columbus, Ohio, 2001

  • Gold Medal Honor Award, Prosper Meniere’s Society, Zell, Austria, 2003

  • Award of Merit, American Otological Society 138th Annual Spring Meeting COSM, Boca Raton, Florida 2005

  • Co-founder: Association for Research in Otolaryngology (established in 1973)

  • Co-founder:  International Symposium on Recent Advances in Otitis Media

  • Organized International Symposium on Recent Advances in Otitis Media and Post Symposium Research Conference in 1975, 1979, 1983, 1987, 1991, 1995, 1999 and 2003.

  • Three U.S. patents awarded:

  • U.S. Patent # 6,207,157 DHHS Ref. E-228-95/0 with Xin Xing Gu, C.M. Tsai, J.S. Robbins: Conjugate Vaccine for nontypeable Haemophilus influenzae, 3/2001

  • U.S. Patent # 6,358,688 6862-101 (09902812) with Y.M. Chun, J.S. Rhim, D.E. Brackmann: Immortalized Human Middle Ear Epithelial Cell Line, 3/2002

  • U.S. Patent # 6,716,813 B2 (09/998,547) with H.Y. Lee, P. Webster, A. Andalibi, J.D. Li, T. Ganz: Use of Antimicrobial Proteins and Peptides for the Treatment of Otitis Media and Paranasal Sinusitis, 4/2004

  • Forty-three research grants and ten research contracts from the Federal government (NIH,

  • NASA, U.S. Air Force, U.S. Army) and private foundations since 1969. 

  • Fifteen research conference grants awarded from NIH since 1975.

Selected Publications (from a total of 250):

Lee, H.Y., Andalibi, A., Webster, P., Moon, S.K., Teufert, K., Kang, S.H., Li, J.D., Nagura, M., Ganz, T., Lim, D.J. (2004) Antimicrobial activity of innate immune molecules against Streptococcus pneumoniae, Moraxella catarrhalis and nontypeable Haemophilus influenzae. BMC Infect Dis. 4: 12.

Watanabe, T., Jono, H., Han, J., Lim, D.J. and Li, J.D. (2004) Synergistic activation of NF-kappaB by nontypeable Haemophilus influenzae and tumor necrosis factor alpha. Proc Natl Acad Sci U S A. 101: 3563-3568.

Jono, H., Xu, H., Kai, H., Lim, D.J., Kim, Y.S., Feng, X.H. and Li, J.D. (2003) Transforming growth factor-beta-Smad signaling pathway negatively regulates nontypeable Haemophilus influenzae-induced MUC5AC mucin transcription via mitogen-activated protein kinase (MAPK) phosphatase-1-dependent inhibition of p38 MAPK. J Biol Chem. 278: 27811-27819.

Kalinec, G.M., Webster, P., Lim, D.J. and Kalinec, F. (2003) A cochlear cell line as an in vitro system for drug ototoxicity screening. Audiol Neurootol. 8: 177-189.

Rueda, J., Cantos, R. and Lim, D.J. (2003) Distribution of glycoconjugates during cochlea development in mice: light microscopic lectin study. Anat Rec A Discov Mol Cell Evol Biol. 274: 923-933.

Chun, Y.M., Moon, S.K., Lee, H.Y., Webster, P., Brackmann, D.E., Rhim, J.S. and Lim, D.J. (2002) Immortalization of normal adult human middle ear epithelial cells using a retrovirus containing the E6/E7 genes of human papillomavirus type 16. Ann Otol Rhinol Laryngol. 111: 507-517.

Jin, S., Moon, S.K., Gu, X.X., Ueyama, S., Rhim, J.S. and Lim, D.J. (2002) Immortalization of rat eustachian tube epithelial cells by adenovirus 12-simian virus 40 hybrid virus. Ann Otol Rhinol Laryngol. 111: 919-925.

Jono, H., Shuto, T., Xu, H., Kai, H., Lim, D.J., Gum, J.R., Jr., Kim, Y.S., Yamaoka, S., Feng, X.H., Li, J.D. (2002) Transforming growth factor-beta -Smad signaling pathway cooperates with NF-kappa B to mediate nontypeable Haemophilus influenzae-induced MUC2 mucin transcription. J Biol Chem. 277: 45547-45557.

Moon, S.K., Lee, H.Y., Li, J.D., Nagura, M., Kang, S.H., Chun, Y.M., Linthicum, F.H., Ganz, T., Andalibi, A., Lim, D.J. (2002) Activation of a Src-dependent Raf-MEK1/2-ERK signaling pathway is required for IL-1alpha-induced upregulation of beta-defensin 2 in human middle ear epithelial cells. Biochim Biophys Acta. 1590: 41-51.

Shuto, T., Imasato, A., Jono, H., Sakai, A., Xu, H., Watanabe, T., Rixter, D.D., Kai, H., Andalibi, A., Linthicum, F., Guan, Y.L., Han, J., Cato, A.C., Lim, D.J., Akira, S., Li, J.D. (2002) Glucocorticoids synergistically enhance nontypeable Haemophilus influenzae-induced Toll-like receptor 2 expression via a negative cross-talk with p38 MAP kinase. J Biol Chem. 277: 17263-17270.

Wang, B., Lim, D.J., Han, J., Kim, Y.S., Basbaum, C.B. and Li, J.D. (2002) Novel cytoplasmic proteins of nontypeable Haemophilus influenzae up-regulate human MUC5AC mucin transcription via a positive p38 mitogen-activated protein kinase pathway and a negative phosphoinositide 3-kinase-Akt pathway. J Biol Chem. 277: 949-957.

Shuto, T., Xu, H., Wang, B., Han, J., Kai, H., Gu, X.X., Murphy, T.F., Lim, D.J., Li, J.D. (2001) Activation of NF-kappa B by nontypeable Hemophilus influenzae is mediated by toll-like receptor 2-TAK1-dependent NIK-IKK alpha /beta-I kappa B alpha and MKK3/6-p38 MAP kinase signaling pathways in epithelial cells. Proc Natl Acad Sci U S A. 98: 8774-8779.

Lim, D.J., Ohashi, Y., Chung, M.H. and DeMaria, T.F. (1989) Animal model for influenza A otitis media. Pediatr Infect Dis J. 8: S38-40.

Bakaletz, L.O., Tallan, B.M., Hoepf, T., DeMaria, T.F., Birck, H.G. and Lim, D.J. (1988) Frequency of fimbriation of nontypable Haemophilus influenzae and its ability to adhere to chinchilla and human respiratory epithelium. Infect Immun. 56: 331-335.

Bakaletz, L.O., DeMaria, T.F. and Lim, D.J. (1987) Phagocytosis and killing of bacteria by middle ear macrophages. Arch Otolaryngol Head Neck Surg. 113: 138-144.

Lim, D.J. (1987) Development of the tectorial membrane. Hear Res. 28: 9-21.

Hanamure, Y. and Lim, D.J. (1986) Normal distribution of lysozyme- and lactoferrin-secreting cells in the chinchilla tubotympanum. Am J Otolaryngol. 7: 410-425.

Lim, D.J. (1986) Functional structure of the organ of Corti: a review. Hear Res. 22: 117-146.

Lim, D.J. and Anniko, M. (1985) Developmental morphology of the mouse inner ear. A scanning electron microscopic observation. Acta Otolaryngol Suppl. 422: 1-69.

Lim, D.J. and Flock, A. (1985) Ultrastructural morphology of enzyme-dissociated cochlear sensory cells. Acta Otolaryngol. 99: 478-492.

Okazaki, N. ,DeMaria, T.F., Briggs, B.R., and Lim, D.J. (1984) Experimental otitis media with effusion following middle ear inoculation of nonviable H influenzae. Ann Otol Rhinol Laryngol. 93: 52-56.

Lim, D.J. (1984) Otoconia in health and disease. A review. Ann Otol Rhinol Laryngol Suppl. 112: 17-24.

Mogi, G., Lim, D.J. and Watanabe, N. (1982) Immunologic study on the inner ear. Immunoglobulins in perilymph. Arch Otolaryngol. 108: 270-275.

Lim, D.J., Liu, Y.S. and Birck, H. (1976) Secretory lysozyme of the human middle ear mucosa: immunocytochemical localization. Ann Otol Rhinol Laryngol. 85: 50-60.

Lim, D.J. and Erway, L.C. (1974) Influence of manganese on genetically defective otolith. A behavioral and morphological study. Ann Otol Rhinol Laryngol. 83: 565-581.

Lim, D.J. and Shimada, T. (1971) Secretory activity of normal middle ear epithelium. Scanning and transmission electron microscopic observations. Ann Otol Rhinol Laryngol. 80: 319-329.


David J. Lim, M.D.

Chief, Section on Pathogenesis of Ear Diseases

e-mail: dlim@hei.org